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Total Syntheses of Tubulysins

✍ Scribed by Taku Shibue; Toshihiro Hirai; Dr. Iwao Okamoto; Dr. Nobuyoshi Morita; Dr. Hyuma Masu; Prof. Dr. Isao Azumaya; Prof. Dr. Osamu Tamura


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
356 KB
Volume
16
Category
Article
ISSN
0947-6539

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Total Synthesis of Tubulysins U and V
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✍ Alexander Dömling; Barbara Beck; Uwe Eichelberger; Sukumar Sakamuri; Sanjay Meno 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB

Tubulysins (1) are compounds of extraordinary potency, rapidly degrading the tubulin cytoskeleton, with tubulysin D being the most active tubulin-modifier known so far. [1,2] The tubulysins were first described by Höfle, Reichenbach, and co-workers in 2000. [3,4] Several representatives are active w

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Total Synthesis of Tubulysin U and V
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