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Topology of a ternary complex (proparacaine–β-cyclodextrin–liposome) by STD NMR

✍ Scribed by Luís Fernando Cabeça; Sergio Antonio Fernandes; Eneida de Paula; Anita Jocelyne Marsaioli

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
182 KB
Volume
46
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The topologies of proparacaine (PPC) in β‐cyclodextrin (β‐CD), PPC in egg phosphatidylcholine (EPC) liposomes and PPC in β‐CD in EPC were investigated using NMR experiments (1D ROESY and saturation transfer difference (STD)). This is the first description of the STD technique applied to PPC–EPC–β‐CD system, revealing that not only PPC was imbedded in EPC bilayer, but β‐CD was also interacting with liposome vesicles. These results are novel and were rationalized as the spontaneous formation of a ternary complex with some β‐CD molecules bound to external liposome vesicles surfaces. Copyright © 2008 John Wiley & Sons, Ltd.

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Prilocaine–cyclodextrin–liposome: effect
Prilocaine–cyclodextrin–liposome: effect of pH variations on the encapsulation and topology of a ternary complex using 1H NMR
✍ Luís Fernando Cabeça; Isis Martins Figueiredo; Eneida de Paula; Anita Jocelyne M 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 145 KB

## Abstract A better comprehension of the prilocaine (PLC)–β‐cyclodextrin (β‐CD) complex liberation to membranes was provided by studying the architectural supramolecular arrangements of PLC, β‐CD and egg phosphatidylcholine (EPC) liposomes, a membrane model. The topologies and possible interaction