Topology and regulation of ganglioside synthesis
โ Scribed by Sandhoff, K.
- Book ID
- 123578625
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 87 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0197-0186
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The synthesis of the ganglioside LM1 (1) has been performed xanthate 5 and tetrasaccharide 6 in the presence of phenylsulfenyl triflate. The tetrasaccharide acceptor 6 was by glycosidation of 2 with azidosphingosine 3, followed by reduction of the azido group, acylation with stearine prepared from
Recently, glycoconjugates, especially gangliosides which contain sialic acid as an essential constituent, have received much attention owing to their important biological functions (2-111. We have had a program in this area, and our efforts resulted in the development of a facile procedure for the c