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Synthesis of Neolacto Ganglioside LM1

✍ Scribed by Lutz F. Tietze; Christian O. Janssen; Jan-Arne Gewert

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 515 KB
Volume: 1998
Category: Article
ISSN: 1434-193X
DOI: 10.1002/(sici)1099-0690(199809)1998:9<1887::aid-ejoc1887>3.0.co;2-i

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✦ Synopsis

The synthesis of the ganglioside LM1 (1) has been performed

xanthate 5 and tetrasaccharide 6 in the presence of phenylsulfenyl triflate. The tetrasaccharide acceptor 6 was by glycosidation of 2 with azidosphingosine 3, followed by reduction of the azido group, acylation with stearine prepared from the lactose derivatives 7 and 8. anhydride (4), and solvolysis. 2 was obtained from sialyl

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