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Toll-like receptor-9 agonists increase cyclin D1 expression partly through activation of activator protein-1 in human oral squamous cell carcinoma cells

✍ Scribed by Ruan Min; Li Siyi; Yang Wenjun; Liu Shengwen; Andrew Ow; Wang Lizheng; Zhang Chenping


Book ID
117940896
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
617 KB
Volume
103
Category
Article
ISSN
1347-9032

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## Abstract Cyclin D1 is a well‐known cell cycle regulator. Recently, its pro‐survival function has been revealed in several tumors. Because increasing expression of cyclin D1 is a common event in oral squamous cell carcinoma (OSCC) and has been correlated with cisplatin resistance, we investigated