Iron increases MMP-9 expression through activation of AP-1 via ERK/Akt pathway in human head and neck squamous carcinoma cells
✍ Scribed by Ruchadaporn Kaomongkolgit; Poonlarp Cheepsunthorn; Prasit Pavasant; Neeracha Sanchavanakit
- Book ID
- 113832932
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 638 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1368-8375
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We previously reported that human head and neck squamous cell carcinomas (HNSCCs) express the proinflammatory and pro-angiogenic cytokines interleukin (IL)-1a, IL-6, IL-8, and granulocyte-macrophage colonystimulating factor in vitro and in vivo. The promoter region of the genes encoding these cytoki
## Abstract We previously reported that expression of angiogenesis factors interleukin‐8 (IL‐8) and vascular endothelial growth factor (VEGF) is promoted by coactivation of transcription factors nuclear factor‐kappaB (NF‐κB) and activator protein‐1 (AP‐1) by interleukin‐1α in human head and neck sq