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Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

✍ Scribed by Chow, J. C.; Young, D. W.; Golenbock, D. T.; Christ, W. J.; Gusovsky, F.

Book ID
124169522
Publisher
The American Society for Biochemistry and Molecular Biology
Year
1999
Tongue
English
Weight
777 KB
Volume
274
Category
Article
ISSN
0021-9258

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Vertebrates and invertebrates initiate a series of defence mechanisms following infection by Gram-negative bacteria by sensing the presence of lipopolysaccharide (LPS), a major component of the cell wall of the invading pathogen. In humans, monocytes and macrophages respond to LPS by inducing the ex