Tolerance to the effects of buprenorphine on schedule-controlled behavior and analgesia in rats
โ Scribed by Charles W. Berthold III; Joseph M. Moerschbaecher
- Book ID
- 113221675
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 394 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0091-3057
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The development of tolerance to behavioral effects of morphine was investigated in rats that responded on a two-lever, multiple-trial, multiple differential-reinforcement-of-low-rate fixed-ratio (mult DRL FR) schedule of food presentation. Stable performances were maintained when sessions were condu
Responding of pigeons was maintained under a multiple fixed interval, fixed ratio schedule of food delivery, and 10 mg/kg morphine was administered daily. Responding during both schedule components was initially decreased and measurable tolerance developed to this effect after four daily injections.
Schedule-controlled responding was maintained under a multiple fixed-interval, fixed-ratio schedule in pigeons. Dose-related decreases in response rates were produced by clonidine (0.00a-0.1mg/kg) and morphine (0.3-5.6 mg/kg). Chronic administration of morphine produced (1) tolerance to effects of m