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Tolerance to effects of morphine without cross tolerance to effects of clonidine on schedule-controlled behavior of pigeons

โœ Scribed by Jonathan L. Katz

Publisher
Springer
Year
1986
Tongue
English
Weight
366 KB
Volume
89
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

Schedule-controlled responding was maintained under a multiple fixed-interval, fixed-ratio schedule in pigeons. Dose-related decreases in response rates were produced by clonidine (0.00a-0.1mg/kg) and morphine (0.3-5.6 mg/kg). Chronic administration of morphine produced (1) tolerance to effects of morphine, as evidenced by a decrease in potency of morphine and (2) sensitivity to opioid antagonists, as evidenced by an increase in potency of naloxone. Dose-effect curves for clonidine were not appreciably altered by chronic morphine administration.

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