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Tolerance to Hormones and Receptors in an Idiotypic Network Model

✍ Scribed by Gérard Weisbuch; Rita Maria Zorzenon Dos Santos; Avidan U. Neumann

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
513 KB
Volume
163
Category
Article
ISSN
0022-5193

No coin nor oath required. For personal study only.

✦ Synopsis

Using a simple mathematical model of the Jerne network, we investigate the conditions of antigen presentation that result in tolerance to pairs of antigens with complementary shapes, such as hormones and receptors. This study is motivated by the prevalence of auto-immune diseases involving hormones or neurotransmitters and their respective receptors as self-antigens. The model shows that, in order to ensure full tolerance to coupled antigens in those conditions that ensure tolerance to isolated antigens, both antigens have to be presented simultaneously in similar conditions. This result suggests a possibility for preventing some auto-immune diseases.

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