## BACKGROUND. Suramin, which binds to and blocks autocrine and paracrine growth factors required for the proliferation of neoplastic cells, is a clinically effective antitumor agent against some human tumors; however, efficacy often is limited by toxicity. In this study, suramin treatment was comb
โฆ LIBER โฆ
Saporin toxins directed to basic fibroblast growth factor receptors effectively target human ovarian teratocarcinoma in an animal model
โ Scribed by Pamela Davol; Julie G. Beitz; Margie Mohler; Wenbin Ying; Jennifer Cook; Douglas A. Lappi; A. Raymond Frackelton Jr.
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 713 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
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## BACKGROUND. Basic fibroblast growth factor receptors on DU145 human prostatic carcinoma xenografts serve as targets for the delivery of a growth factor-toxin chimera, basic fibroblast growth factor-saporin (bFGF-SAP), which produces significant antitumor activity in a nude mouse model. However,