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Tolerance to amphetamine-induced impairment of rotarod performance in rats

✍ Scribed by Michael C. Gerald; Tribhuwan K. Gupta; R. Michael Snider

Publisher: Springer
Year: 1979
Tongue: English
Weight: 156 KB
Volume: 61
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00432278

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✦ Synopsis

Acute administration of d-amphetamine sulfate (30 mg/kg, i.p.) caused muscle weakness and 80 % failure in rotarod performance in rats, The incidence of performance failure progressively decreased to 30 % in animals receiving d-amphetamine and tested daily for 8 days. A similar progressive reduction in performance impairment was observed in animals receiving damphetamine for 3, 5, or 7 days (12.5 %) and evaluated only once after the last dose. The tolerance is attributable to a physiological or biochemical rather than learning phenomenon.

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