Development of tolerance to the activating action of morphine, amphetamine, and alcohol on the positive reinforcement system in rats
โ Scribed by Yu. V. Burov; S. A. Borisenko
- Publisher
- Springer US
- Year
- 1980
- Tongue
- English
- Weight
- 243 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0007-4888
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The influence of "learning" on the development of tolerance to the analgesic effect of morphine in rats was examined employing the hot plate procedure. A tested-reinforced (Tr) group and its yoked-control, a tested-non-reinforced (Tnr) group, received identical exposure to the testing procedure; the
Alcohol tolerance, measured as performance on the tilting plane after ethanol injection (2.5 g/kg body weight i.p.), was examined in the AA strain of rats which voluntarily drink large amounts of alcohol, in the ANA strain which drink very little alcohol, and in ordinary albino rats which consume in