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Tolerance and dependence after chronic administration of clonidine to the rat

✍ Scribed by D.R. Meyer; R. El-Azhary; D.WS. Bierer; S.K. Hanson; M.S. Robbins; S.B. Sparber

Book ID
113217302
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
386 KB
Volume
7
Category
Article
ISSN
0091-3057

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Ophthalmological and pharmacological studies after administration of clonidine in rats
✍ I. Weisse; W. Hoefke; S. Greenberg; W. Gaida; H. StΓΆtzer; H. Kreuzer πŸ“‚ Article πŸ“… 1978 πŸ› Springer-Verlag 🌐 English βš– 658 KB

Clonidine (0.3 mg/kg or more p.o.) induced corneal lesions in rats. Amitriptyline did not give rise to such alterations. Biomicroscopically, these clonidine-induced lesions presented as gradually differentiated focal opacities in the superficial layers of the corneal centre. The corneal alterations