Tolerability of everolimus-based immunosuppression in maintenance liver transplant recipients
✍ Scribed by Mélanie Vallin; Olivier Guillaud; Isabelle Morard; Marie-Claude Gagnieu; Gilles Mentha; Mustapha Adham; Emmanuel Morelon; Olivier Boillot; Emiliano Giostra; Jérôme Dumortier
- Book ID
- 110890487
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 181 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0902-0063
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📜 SIMILAR VOLUMES
Everolimus is a macrolide immunosuppressive agent with known consistent absorption. In this double-blind study, we examined the safety and tolerability of everolimus vs. placebo in de novo liver transplant recipients. One hundred and nineteen liver allograft recipients were randomized to 1 of 4 grou
Sirolimus (SRL) has been proposed to replace calcineurin inhibitors (CNI) in case of CNI-induced toxicity. The aim of this study was to evaluate the efficacy and safety of conversion from CNI to SRL in maintenance liver transplantation (LT) patients. Between 2002 and 2006, conversion was performed i
## Key Points 1. Our increasing understanding of the signaling pathways and cellular interactions in transplant immunobiology has facilitated targeted strategies using novel immunosuppressive agents. 2. The pattern of immunosuppressive drug use in the United States continues to change, and the chan
Calcineurin inhibitors (CNIs) contribute to renal dysfunction following liver transplantation. This prospective, randomized, multicenter, 6-month study (with an additional 6 months of follow-up) evaluated whether everolimus with CNI reduction or discontinuation would improve renal function in mainte