Tobramycin kinetics in newborn infants
β Scribed by Milap C. Nahata; Dwight A. Powell; Ronald P. Gregoire; Richard E. McClead; James A. Menke; Rex G. Bickers; John P. Glazer
- Book ID
- 119460514
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 254 KB
- Volume
- 103
- Category
- Article
- ISSN
- 1097-6833
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π SIMILAR VOLUMES
Peak and trough serum concentrations of ceftazidime and tobramycin were determined in neonates with suspected septicaemia in an open randomized study. Mean peak serum levels were 85 (+/- 4.4 SE) mg/l for ceftazidime and 5.8 (+/- 0.3 SE) mg/l for tobramycin. The peak serum levels of ceftazidime were
Thirty-five neonates with suspected septicaemia were randomized to treatment with tobramycin or ceftazidime, both in combination with ampicillin. Concentrations of antibiotics in the CSF were measured lh after the third, fourth or fifth injection. In 13 of 17 neonates tobramycin CSF concentrations w