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Concentrations of ceftazidime, tobramycin and ampicillin in the cerebrospinal fluid of newborn infants

✍ Scribed by I. Tessin; B. Trollfors; K. Thiringer; Z. Thörn; P. Larsson

Publisher
Springer
Year
1989
Tongue
English
Weight
270 KB
Volume
148
Category
Article
ISSN
0340-6997

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✦ Synopsis

Thirty-five neonates with suspected septicaemia were randomized to treatment with tobramycin or ceftazidime, both in combination with ampicillin. Concentrations of antibiotics in the CSF were measured lh after the third, fourth or fifth injection. In 13 of 17 neonates tobramycin CSF concentrations were below 0.5 rag/1. Ceftazidime CSF concentrations ranged from 2.5 to 17mg/1, which should be sufficient for treatment of infections with group B streptococci and most aerobic gram-negative bacilli but not all strains of Staphylococcus aureus. Ampicillin CSF concentrations ranged from 1 to 80 mg/1, which should be sufficient for treatment of meningitis caused by enterococci and Listeria monocytogenes, the most important neonatal pathogens not covered by ceftazidime.

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