✦ LIBER ✦

To be or not to be a responder in T-cell responses: ubiquitous oligopeptides in all proteins

✍ Scribed by Susumu Ohno

Publisher: Springer-Verlag
Year: 1991
Tongue: English
Weight: 653 KB
Volume: 34
Category: Article
ISSN: 0093-7711
DOI: 10.1007/bf00215255

No coin nor oath required. For personal study only.

✦ Synopsis

Amino acid sequences of all proteins are essays written in the same language. Accordingly, the same set of words and phrases (oligopeptides) appear in totally unrelated proteins. The reason that only certain individuals of particular major histocompatibility complex (MHC) haplotypes can mount T-cell responses against a given antigen of pathogens is found in the fact that T-cell receptors are designed to recognize 18-20 residue-long peptide fragments sandwiched between two alpha-helices of class I or class II MHC molecules. At this range of peptide lengths, most would appear as self, while nonselfness of the remainders are destined to be quite ambiguous, hence creating responders and nonresponders.

📜 SIMILAR VOLUMES

To be or not to be NKT: Natural killer T

To be or not to be NKT: Natural killer T cells in the liver

✍ Mark A. Exley; Margaret James Koziel 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 308 KB 👁 1 views

Much of the hepatology literature to date has focused on the adaptive, antigen-specific response mediated by classical T-cell populations in both the protection and pathogenesis of liver disease. However, the liver is selectively enriched for cells representative of innate immunity, including natura

Cellular responses to murine CD40 in a m

Cellular responses to murine CD40 in a mouse B cell line may be TRAF dependent or independent

✍ Eric Manning; Steven S. Pullen; Donald J. Souza; Marilyn Kehry; Randolph J. Noel 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 187 KB 👁 1 views

Predominant and stable T cell responses

Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis

✍ Marco Salvetti; Giovanni Ristori; Mauro D'Amato; Carla Buttinelli; Marika Falcon 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 935 KB

Renal insufficiency and anemia are indep

Renal insufficiency and anemia are independent risk factors for death among patients with acute myocardial infarction1,21As published material, the contents of this manuscript may not be cited, quoted, reproduced or published without the consent of the authors.2The analyses upon which this publication is based were performed under Contract Number 500-96-P704, entitled âOperation Utilization and Quality Control Peer Review Organization (PRO) for the State of Georgiaâ and sponsored by the Centers for Medicare and Medicaid Services (CMS), Department of Health and Human Services. The conclusions and opinions expressed, and methods used herein are those of the authors. They do not necessarily reflect CMS policy. The authors assume full responsibility for the accuracy and completeness of the ideas presented. This article is a direct result of the Health Care Quality Improvement Program initiated by CMS, which has encouraged identification of quality improvement projects derived from analysis of patterns of care, and therefore required no special funding on the part of this Contractor. Ideas and contributions to the authors concerning experience in engaging with issues presented are welcomed.

✍ Langston, Robert D.; Presley, Rodney; Flanders, W. Dana; Mcclellan, William M. 📂 Article 📅 2003 🏛 Nature Publishing Group 🌐 English ⚖ 373 KB