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TNFα increases hypothalamic PTP1B activity via the NFκB pathway in rat hypothalamic organotypic cultures

✍ Scribed by Yoshihiro Ito; Ryoichi Banno; Shigeru Hagimoto; Yoshiharu Ozawa; Hiroshi Arima; Yutaka Oiso

Book ID: 113873857
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 592 KB
Volume: 174
Category: Article
ISSN: 0167-0115
DOI: 10.1016/j.regpep.2011.11.010

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## Abstract The expression of matrix metalloproteinase‐9 (MMP‐9) has been implicated in progression of atherosclerotic lesions. The role and importance of the signaling pathway in the transcriptional regulation of MMP‐9 in human aortic smooth muscle cells (HASMC) was examined. Tumor necrosis factor