TNF-α modulates angiopoietin-1 expression in rheumatoid synovial fibroblasts via the NF-κB signalling pathway
✍ Scribed by B.B. Scott; P.F. Zaratin; A.G. Gilmartin; M.J. Hansbury; A. Colombo; C. Belpasso; J.D. Winkler; J.R. Jackson
- Book ID
- 116289863
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 400 KB
- Volume
- 328
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## Objective To investigate the roles of MAPKs and NF‐κB in tumor necrosis factor α (TNFα)–induced expression of vascular cell adhesion molecule 1 (VCAM‐1) in human rheumatoid arthritis synovial fibroblasts (RASFs). ## Methods Human RASFs were isolated from synovial tissue obtained f
## Abstract Tumor necrosis factor α (TNFα) inhibits matrix synthesis by chondrocytes in rheumatoid arthritis and osteoarthritis; however, the underlying signaling pathways are poorly characterized. This study investigated the TNFα‐activated pathways regulating expression of two key components of th