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TNF-α modulates expression of the circadian clock gene Per2 in rheumatoid synovial cells

✍ Scribed by Yoshida, K; Hashiramoto, A; Okano, T; Yamane, T; Shibanuma, N; Shiozawa, S

Book ID
120041107
Publisher
Informa plc
Year
2013
Tongue
English
Weight
193 KB
Volume
42
Category
Article
ISSN
0300-9742

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## Abstract The suprachiasmatic nuclei (SCN) of the hypothalamus contain the master circadian clock in mammals. Nocturnal light pulses that reset the circadian clock also lead to rapid increases in levels of __Per1__ and __Per2__ mRNA in the SCN, suggesting that these genes are involved in the sync