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TNF-related apoptosis-inducing ligand as a therapeutic agent in autoimmunity and cancer*

✍ Scribed by CRETNEY, ERIKA; SHANKER, ANIL; YAGITA, HIDEO; SMYTH, MARK J; SAYERS, THOMAS J

Book ID: 108944559
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 199 KB
Volume: 84
Category: Article
ISSN: 0818-9641
DOI: 10.1111/j.1440-1711.2005.01413.x

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## Abstract Treatment of cancer cells with histone deacetylase inhibitors (HDACi) such as suberolylanilide hydroxamic acid (SAHA) activates genes that promote apoptosis. To enhance proapoptotic efficiency, SAHA has been used in combination with radiation, kinase inhibitors and cytotoxic drugs. Alth