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TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis inApoe−/−mice

✍ Scribed by B. A. Di Bartolo; J. Chan; M. R. Bennett; S. Cartland; S. Bao; B. E. Tuch; M. M. Kavurma

Book ID: 105820384
Publisher: Springer
Year: 2011
Tongue: English
Weight: 461 KB
Volume: 54
Category: Article
ISSN: 0012-186X
DOI: 10.1007/s00125-011-2308-0

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## Abstract Treatment of cancer cells with histone deacetylase inhibitors (HDACi) such as suberolylanilide hydroxamic acid (SAHA) activates genes that promote apoptosis. To enhance proapoptotic efficiency, SAHA has been used in combination with radiation, kinase inhibitors and cytotoxic drugs. Alth