TLC identification and GLC determination of meperidine and its metabolites in biological fluids
โ Scribed by S. Y. Yeh; H. A. Krebs
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 555 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
A sensitive and specific GLC assay was developed for acetohexamide and hydroxyhexamide, its major metabolite, in plasma and urine. The assay uses tolbutamide as a mass internal standard. Compounds are extracted from acidified plasma or urine with toluene, converted to methylated derivatives with dim
ping m, methylenes and methines), 3.59 (s, 3H, vinyl methoxy), 3.64 and 3.66 (as, 3H total, carbomethoxy), 3.72 (d, lH, J = about 10 Hz, benzylic proton on C-41, 5.00 (s, lH, vinyl), 5.82 (s and an indistinct overlapping signal, 2H plus lH, methylenedioxy and proton on C-3), and 6. 64 and 6.67 (2s,