Title: Application of non-radioactive in situ hybridization in the detection of chromosome 12 aberrations in human germ cell tumors.
β Scribed by R. Suijkerbuijk; B. de Leeuw; B. de Jong; J.W. Oosterhuis; L. Looijenga; J.J. Cassiman; D. Schonk; H.H. Ropers; A. Geurts van Kessel
- Book ID
- 119105260
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 59 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0165-4608
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## Abstract The i(12p) marker chromosome has been found to be a highly nonrandom chromosome abnormality associated with germ cell tumors (GCTs). We have previously shown that a chromosome 12 centromere specific Ξ±βsatellite DNA probe detects the i(12p) by virtue of differences in the size of the sig
The distribution of segments of the short and long arms of chromosome I 2 was distinguished by two-color fluorescence in situ hybridization (FISH) in 27 cytogenetically abnormal testicular germ cell tumors (TGCTs). A I 2p-specific probe was developed by chromosomal microdissection and sequence-indep