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Titelbild: Flattened Cone 2,8,14,20-Tetrakis(L-valinamido)[4]resorcinarene: An Enantioselective Allosteric Receptor in the Gas Phase (Angew. Chem. 17/2006)

✍ Scribed by Bruno Botta; Fabiana Caporuscio; Deborah Subissati; Andrea Tafi; Maurizio Botta; Antonello Filippi; Maurizio Speranza

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
168 KB
Volume
118
Category
Article
ISSN
0044-8249

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✦ Synopsis

Proteinallosterie bildet die Grundlage für die molekulare Kontrolle fundamentaler Prozesse in lebenden Systemen, doch trotz ihrer Bedeutung sind zentrale mechanistische Fragen noch unbeantwortet. Zu deren Klärung nutzten M. Speranza et al. in ihrer Zuschrift auf S. 2783 ff. einen Gasphasenansatz. Dabei verliert der achirale, hydrophobe Rand eines chiralen Resorcin[4]arens durch Einwirkung von 2‐Aminobutan hoch enantioselektiv D‐ und L‐Tryptophan.

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Cover Picture: Flattened Cone 2,8,14,20-
Cover Picture: Flattened Cone 2,8,14,20-Tetrakis(L-valinamido)[4]resorcinarene: An Enantioselective Allosteric Receptor in the Gas Phase (Angew. Chem. Int. Ed. 17/2006)
✍ Bruno Botta; Fabiana Caporuscio; Deborah Subissati; Andrea Tafi; Maurizio Botta; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB

**__Protein allosterism__** is the basis for the molecular control of fundamental processes in living systems, but despite its importance, basic questions on the mechanisms involved remain unanswered. A gas‐phase approach to the problem is described by M. Speranza et al. in their Communication on pa