Cover Picture: Flattened Cone 2,8,14,20-Tetrakis(L-valinamido)[4]resorcinarene: An Enantioselective Allosteric Receptor in the Gas Phase (Angew. Chem. Int. Ed. 17/2006)

✍ Scribed by Bruno Botta; Fabiana Caporuscio; Deborah Subissati; Andrea Tafi; Maurizio Botta; Antonello Filippi; Maurizio Speranza

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 169 KB
• Volume: 45
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200690060

✦ Synopsis

Protein allosterism is the basis for the molecular control of fundamental processes in living systems, but despite its importance, basic questions on the mechanisms involved remain unanswered. A gas‐phase approach to the problem is described by M. Speranza et al. in their Communication on page 2717 ff., in which they report the highly enantioselective, 2‐aminobutane‐induced loss of D‐ and L‐tryptophan from the achiral hydrophobic rim of a chiral resorcin[4]arene.