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Titelbild: Contribution of Ligand Desolvation to Binding Thermodynamics in a Ligand–Protein Interaction (Angew. Chem. 38/2006)

✍ Scribed by Natalia Shimokhina; Agnieszka Bronowska; Steve W. Homans

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
142 KB
Volume
118
Category
Article
ISSN
0044-8249

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Cover Picture: Contribution of Ligand De
Cover Picture: Contribution of Ligand Desolvation to Binding Thermodynamics in a Ligand–Protein Interaction (Angew. Chem. Int. Ed. 38/2006)
✍ Natalia Shimokhina; Agnieszka Bronowska; Steve W. Homans 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB 👁 2 views

**Ligand–protein interactions** are associated with the desolvation of a ligand as it enters the protein‐binding pocket (see cover picture). Homans and co‐workers describe in their Communication on page 6374 ff. an estimate of the thermodynamic cost associated with this desolvation process. These da