Cover Picture: Contribution of Ligand Desolvation to Binding Thermodynamics in a Ligand–Protein Interaction (Angew. Chem. Int. Ed. 38/2006)

✍ Scribed by Natalia Shimokhina; Agnieszka Bronowska; Steve W. Homans

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 142 KB
• Volume: 45
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200690128

✦ Synopsis

Ligand–protein interactions are associated with the desolvation of a ligand as it enters the protein‐binding pocket (see cover picture). Homans and co‐workers describe in their Communication on page 6374 ff. an estimate of the thermodynamic cost associated with this desolvation process. These data permit a complete breakdown of the binding thermodynamics into contributions from the ligand, protein, and solvent for the interaction of a small‐molecule ligand with the mouse major urinary protein.