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Titanium(IV) Bromide Promoted Diastereoselective Reactions of Arylaldehydes with Optically Active Propiolates.

✍ Scribed by Min Shi; Chun-Jiang Wang


Book ID
101966368
Publisher
John Wiley and Sons
Year
2004
Weight
121 KB
Volume
35
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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Optically active 5-hydroxy-3-oxoesters 1 can be obtained in up to 91% enantiomeric excess (e.e.) by the enantioselective reaction of diketene with aldehydes promoted by novel chiral Schiff base,---titanium alkoxide complexes. Optically active derivatives 1 can be converted into 6-substituted 4-hydr