Highly efficient preparation of opticall
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Masahiko Hayashi; Kiyoshi Tanaka; Nobuki Oguni
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Article
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1995
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Elsevier Science
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English
โ 199 KB
Optically active 5-hydroxy-3-oxoesters 1 can be obtained in up to 91% enantiomeric excess (e.e.) by the enantioselective reaction of diketene with aldehydes promoted by novel chiral Schiff base,---titanium alkoxide complexes. Optically active derivatives 1 can be converted into 6-substituted 4-hydr