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Titanium-Mediated Synthesis of Primary Cyclopropylamines from Nitriles and Grignard Reagents

โœ Scribed by Bertus, Philippe; Szymoniak, Jan

Book ID
121722102
Publisher
Thieme Medical Publishers
Year
2007
Tongue
English
Weight
261 KB
Volume
2007
Category
Article
ISSN
0936-5214

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๐Ÿ“œ SIMILAR VOLUMES

Titanium-mediated synthesis of bicyclic
Titanium-mediated synthesis of bicyclic cyclopropylamines from unsaturated nitriles
โœ Christophe Laroche; Philippe Bertus; Jan Szymoniak ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 103 KB

Here we report an easy synthesis of bicyclic primary cyclopropylamines directly from unsaturated nitriles. The described reaction involves Ti(II)-mediated intramolecular coupling of alkene and nitrile moieties.