Titanium Alloys for Biomedical Development and Applications: Design, Microstructure, Properties, and Application

✍ Scribed by Zhentao Yu

• Publisher: Elsevier
• Year: 2022
• Tongue: English
• Leaves: 246
• Category: Library

✦ Synopsis

Titanium Alloys for Biomedical Development and Applications: Design, Microstructure, Properties and Application systematically introduces basic theories and progress in the research of biomedical ß-Ti alloys achieved by researchers from different fields. It focuses on a high-strength and low elastic modulus biomedical ß-Ti alloy (TLM), etc. designed by the authors. The alloy design methods, microstructural characteristics, mechanical properties, surface treatment methods and biocompatibility of the TLM alloy are discussed in detail, along with a concise description of the medical devices made from this alloy and the application examples.

This book will appeal to researchers as well as students from different disciplines, including materials science, biology, medicine and engineering fields.

✦ Table of Contents

Front Cover
Titanium Alloys for Biomedical Development and Applications
Copyright Page
Contents
List of contributors
Preface
1 Overview of the development and application of biomedical metal materials
1.1 Biomedical stainless steels
1.1.1 Overview of biomedical stainless steels
1.1.2 Nickel-free austenitic stainless steels
1.1.3 Antibacterial stainless steels
1.1.4 Application
1.2 Biomedical CoCr alloys
1.2.1 Overview of CoCr alloys
1.2.2 Typical microstructure and properties of CoCr alloys
1.2.3 Typical application of CoCr alloys
1.3 Biomedical shape memory alloys
1.3.1 Overview of shape memory alloys
1.3.2 Typical composition and brand of shape memory alloys
1.3.3 Typical application of NiTi shape memory alloys
1.4 Biomedical noble metals
1.4.1 Dental materials
1.4.2 Acupuncture materials
1.4.3 Medicinal precious metals
1.4.4 Surgical materials
1.5 Biomedical refractory metals
1.5.1 Overview of biomedical refractory metals
1.5.2 Preparation and evaluation of porous tantalum
1.5.3 Porous tantalum application
1.6 Ti and its alloys
1.6.1 The first generation of biomedical Ti alloys
1.6.2 The second generation of biomedical Ti alloys
1.6.3 The third generation of biomedical Ti alloys
1.7 Degradable metals
1.7.1 Magnesium alloys
1.7.2 Zinc alloys
References
2 Design and physical metallurgy of biomedical β-Ti alloys
2.1 Overview of design methods of biomedical Ti alloys
2.1.1 d-Electron theory for Ti alloy design
2.1.2 Mo equivalent for Ti alloy design
2.2 Overview of composition design of biomedical Ti alloys
2.3 Overview of the design and development of typical biomedical β-Ti alloys
2.4 Smelting and physical metallurgical properties of typical β-Ti alloys
2.4.1 Review of the smelting of β-type Ti alloys
2.4.2 TiTa alloys
2.4.3 TiNbTaZr alloys
2.4.4 TiZr alloys
2.4.5 TiNb alloys
2.5 Design and physical metallurgical properties of novel TLM alloy
2.5.1 Design of novel TLM alloy
2.5.2 Smelting and physical metallurgical properties of TLM alloy
References
3 Processing, heat treatment, microstructure, and property evolution of TLM alloy
3.1 Overview of processing and heat treatment of β-Ti alloys
3.2 Billets and semifinished products of TLM alloy
3.3 Plates and strips of TLM alloy
3.4 Bars and rods of TLM alloy
3.5 Tubes of TLM alloy
3.5.1 Hot extrusion tube of TLM alloy
3.5.2 Cold rolled tube of TLM alloy
3.5.3 Relationship among processing, microstructure, and properties of TLM alloy tubes
3.6 TLM alloy products with special specifications
3.6.1 TLM alloy tubes with small diameters and thin walls
3.6.2 TLM alloy tubes with thin walls and variable diameters
3.6.3 TLM alloy wires
3.7 TLM alloy foils
3.7.1 Summary of severe plastic deformation (SPD) processing technology
3.7.2 TLM alloy foil by novel SPD process
References
4 Biological and mechanical evaluation of TLM alloy
4.1 Biological evaluation of TLM alloy
4.1.1 Biological corrosion behavior
4.1.2 Hemolysis
4.1.3 Cytotoxicity
4.1.4 Genotoxicity
4.1.5 Chronic toxicity
4.1.6 Skin sensitization and irritation
4.1.7 Oral irritation
4.1.8 Intradermal reaction
4.1.9 Subcutaneous, muscle, and bone implantation
4.2 Biomechanical compatibility of TLM alloy
4.2.1 Conception of biomechanical compatibility
4.2.2 Phase transformation and biomechanical match of TLM alloy
4.2.3 Grain refinement and the match of strength and toughness of TLM alloy
4.2.4 Superelasticity of TLM alloy
4.2.5 Shape memory capability of TLM alloy
4.2.6 High-cycle fatigue deforming performance of TLM alloy
4.2.7 Low-cycle fatigue deforming performance of TLM alloy
4.2.8 Dynamic fracture toughness of TLM alloy
4.2.9 Wearability of TLM alloy
References
5 Surface modification and functionalization of TLM alloy
5.1 Surface modification of Ti alloys
5.2 Surface functionalization of Ti alloys
5.2.1 Surface bioactive modification of metals for repairing bones/teeth hard tissues
5.2.2 Anticoagulant surface modification for cardiovascular stents
5.2.3 Wear-resistant surface modification of metals for replacement of hard tissues
5.3 Surface dealloying of TLM alloy
5.4 Bioactive coatings on TLM alloy
5.4.1 Preparation of porous bioactive coatings by microarc oxidation
5.4.2 Preparation of strontium-containing bioactive coatings by microarc oxidation
5.4.3 Preparation of barium titanate bioactive coatings by microarc oxidation
5.4.4 Preparation of TiO2 nanotube bioactive films by anodic oxidation
5.5 Wear-resistant coatings on TLM alloy
5.5.1 Surface hardening modification on TLM alloy
5.5.2 Surface hardness and corrosion resistance of TLM alloy
5.6 Anticoagulant coatings on TLM alloy
5.6.1 Preparation and activation of TiO2 films
5.6.2 Self-assembly of heparin and albumin
5.6.3 Surface characterization of composite coatings
5.6.4 Characterization of blood compatibility of composite coatings
5.7 Antimicrobial coatings on TLM alloy
5.7.1 Preparation and phase characterization of antimicrobial coatings
5.7.2 Characterization of surface morphology of coatings
5.7.3 Characterization of antimicrobial properties of coatings
References
6 Development and application of TLM alloy for the replacement and repair of surgical implants
6.1 Development and application of traditional Ti implants
6.2 Design and novel manufacture of Ti implants
6.3 Implants for orthopedics and trauma repair
6.3.1 Design of bone plates
6.3.2 Processing and pretreatment for the forging of bone plates
6.3.3 Hot forging simulation
6.4 Implants for joint repair and replacement
6.4.1 Design of a TLM femoral stem
6.4.2 Mechanical simulation of the designed hip joint prosthesis
6.4.3 Dynamic mechanical simulation and biotribological analysis of the designed hip joint prosthesis
6.4.4 Manufacture process of a TLM femoral stem
6.5 Implants for oral and maxillofacial repair and replacement of TLM alloy
6.5.1 The structural design of a TLM dental implant
6.5.2 Structural simulation optimization and biomechanical analysis of TLM dental implants
6.5.2.1 The structural optimization of a TLM dental implant
6.5.2.2 Biomechanical CAE analysis of a TLM dental implant
6.5.3 Precision machining of TLM alloy dental implants
6.6 Medical devices of TLM alloy for spine repair
6.6.1 Fixation system for spine
6.6.2 Other medical devices made of TLM alloy for spine repair
References
7 Development and application of TLM alloy for treatment of soft tissue with minimally invasive surgery
7.1 Development and application survey of minimally invasive devices
7.2 Design and manufacture survey of interventional devices
7.3 Coronary stents of TLM alloy
7.3.1 Stent pattern selection of TLM alloy
7.3.2 Radial support force of a TLM alloy stent
7.3.3 Retraction rate test and finite element analysis of a TLM alloy stent
7.3.4 Processing and postprocessing of a TLM alloy stent
7.4 Nonvascular stents and related devices of TLM alloy
7.4.1 Larynx and trachea prosthesis of TLM alloy
7.4.2 Laryngeal repair tube-type devices of TLM alloy
7.4.3 Blood circulation pipe fittings of TLM alloy
7.5 Shell of brain and heart active devices of TLM alloy
7.5.1 Model establishment
7.5.2 Influence of process parameters
7.6 Other minimally invasive and interventional devices of TLM alloy
Reference
Index
Back Cover