Glutamate excitotoxicity has been suggested to contribute to the pathogenesis of Huntington's disease (HD). Riluzole is a substance with glutamate antagonistic properties that is used for neuroprotective treatment in amyotrophic lateral sclerosis and which is currently tested in clinical trials for
✦ LIBER ✦
‘Tissue’ transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease
✍ Scribed by Mastroberardino, P G; Iannicola, C; Nardacci, R; Bernassola, F; De Laurenzi, V; Melino, G; Moreno, S; Pavone, F; Oliverio, S; Fesus, L
- Book ID
- 110016425
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 454 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1350-9047
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## Abstract Patients with Huntington's disease have an expanded polyglutamine tract in huntingtin and suffer severe brain atrophy and neurodegeneration. Because membrane dysfunction can occur in Huntington's disease, we addressed whether mutant huntingtin in brain and primary neurons is present in