MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease

Activation of the extracellular signal-r

Activation of the extracellular signal-regulated kinases 1 and 2 by glial cell line-derived neurotrophic factor and its relation to neuroprotection in a mouse model of Parkinson's disease

✍ Niklas Lindgren; Rehana K. Leak; Kirsten M. Carlson; Amanda D. Smith; Michael J. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 851 KB

## Abstract Glial cell line‐derived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signal‐regulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDN