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Tissue-specific induction of sister chromatid exchanges by ethyl carbamate in mice

✍ Scribed by Roberts, Gladwin T. ;Allen, James W.

Publisher
Wiley (John Wiley & Sons)
Year
1980
Weight
667 KB
Volume
2
Category
Article
ISSN
0192-2521

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This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m