Tissue inhibitor of metalloproteinases-1 promotes liver fibrosis development in a transgenic mouse model
β Scribed by Hitoshi Yoshiji; Shigeki Kuriyama; Yoji Miyamoto; Unnur P. Thorgeirsson; Daniel E. Gomez; Mitsuhiro Kawata; Junichi Yoshii; Yasuhide Ikenaka; Ryuichi Noguchi; Hirohisa Tsujinoue; Toshiya Nakatani; Snorri S. Thorgeirsson; Hiroshi Fukui
- Book ID
- 111721236
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 648 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0270-9139
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## Abstract The tissue inhibitor of matrix metalloproteinasesβ1 (TIMPβ1) has been recognized as a multifunctional protein. The role of TIMPs in cancer remains the subject of conflicting reports with an antitumor activity or a tumor growth stimulation activity by several mechanisms. The aim of our s
Liver fibrosis is characterized by increased synthesis, and decreased degradation, of extracellular matrix (ECM) within the injured tissue. Decreased ECM degradation results, in part, from increased expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), which blocks matrix metalloproteinase