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Tissue inhibitor of metalloproteinases-1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse

✍ Scribed by Yoshiji, H


Book ID
121902638
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
600 KB
Volume
36
Category
Article
ISSN
0270-9139

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Liver fibrosis is characterized by increased synthesis, and decreased degradation, of extracellular matrix (ECM) within the injured tissue. Decreased ECM degradation results, in part, from increased expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), which blocks matrix metalloproteinase