Tissue Hypoxia and Ischemia

✍ Scribed by Frans F. Jobsis (auth.), Martin Reivich, Ronald Coburn, Sukhamay Lahiri, Britton Chance (eds.)

• Publisher: Springer US
• Year: 1977
• Tongue: English
• Leaves: 381
• Series: Advances in Experimental Medicine and Biology 78
• Edition: 1
• Category: Library

✦ Synopsis

This monograph contains the proceedings of a symposium entitled, "Tissue Hypoxia and Ischemia," which was held at the Annenberg Center of the University of Pennsylvania on August 13 and 14, 1976. The symposium was jointly sponsored by the following groups at the University of Pennsylvania: the Respiratory Physiology Group of the Department of Physio­ logy, the Cardiopulmonary Section of the Department of Medicine, the Johnson Research Foundation, the Cerebrovascular Research Center of the Department of Neurology, the Head Injury Center of the Department of Neurosurgery, the. Institute for Environ­ mental Medicine, and the International Society on Oxygen Transport to Tissues. Its purpose was to promote an interdisciplinary discussion of oxygen sensors in various tissues and their mechanism of action as well as to examine the deleterious effects of hypoxia and ischemia with special reference to the brain. There were four sessions, one on the biochemistry of physi­ ologic oxygen sensors, two on the mechanism of oxygen sensing in tissues and one on the circulatory and metabolic aspects of cerebral hypoxia and ischemia.

✦ Table of Contents

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
What is a Molecular Oxygen Sensor? What is a Transduction Process?....Pages 3-18
The Oxygen Sensing Characteristics of Microsomal Enzymes....Pages 19-35
Oxygen Sensing Heme Proteins: Monoxygenases, Myoglobin and Hemoglobin....Pages 37-50
Peroxisomal Enzymes and Oxygen Metabolism in Liver....Pages 51-66
Mitochondrial Production of Superoxide Radical and Hydrogen Peroxide....Pages 67-82
Front Matter....Pages 83-83
Chemoreception and Transduction on Neuronal Models....Pages 85-100
Oxygen Tension Sensors in Vascular Smooth Muscle*....Pages 101-115
Comments on: Oxygen Tension Sensors in Vascular Smooth Muscle....Pages 117-122
Mechanism of Oxygen Induced Contraction of Ductus Arteriosus....Pages 123-134
Prostaglandins and the Control of Muscle Tone in the Ductus Arteriosus....Pages 135-142
The Sensing of Oxygen Tension in the Pulmonary Circulation....Pages 143-150
The Sensing of Oxygen Tension in the Pulmonary Circulation — Discussion....Pages 151-161
Circulatory Effects of Tissue Oxygen Tension Sensors....Pages 163-174
Bioassay and Pharmacologic Evaluation of the Adenosine Hypothesis....Pages 175-182
Front Matter....Pages 183-183
Introductory Remarks: Oxygen Linked Response of Carotid Chemoreceptors....Pages 185-202
Convergence of Stimuli in Arterial Chemoreceptors....Pages 203-207
Intracellular Studies of Carotid Body Cells: Effects of Temperature, “Natural” Stimuli and Chemical Substances....Pages 209-223
Tissue PO 2 in the Cat Carotid Body and Related Functions....Pages 225-232
Some Aspects of Localization, Depletion, Uptake and Turnover of Catecholamines by Glomus Cells of the Rat Carotid Body....Pages 233-243
Catecholamines and 3′,5′ Cyclic AMP in Carotid Body Chemoreception in the Cat....Pages 245-258
Front Matter....Pages 259-259
Metabolic Aspects of Cerebral Hypoxia-Ischemia....Pages 261-269
Discussion: Metabolic Aspects of Cerebral Hypoxia-Ischemia....Pages 271-274
Regional Changes in Metabolism in Hypoxia-Ischemia....Pages 275-286
Cyclic Nucleotide Levels in the Gerbil Cerebral Cortex, Cerebellum and Spinal Cord Following Bilateral Ischemia....Pages 287-298
Changes in PO 2 and Ion Fluxes in Cerebral Hypoxia-Ischemia....Pages 299-312
Comments On: Changes in PO 2 and Ion Fluxes in Cerebral Hypoxia-Ischemia....Pages 313-317
Events Marking Irreversible Injury....Pages 319-321
Cerebral Hemodynamic and Metabolic Alterations in Stroke....Pages 323-335
Cerebral Hemodynamic and Metabolic Alterations in Stroke: Formal Discussion of Paper by Dr. Martin Reivich, et al.....Pages 337-342
Cerebral Hemodynamic and Metabolic Alterations in Hypovolemic Shock....Pages 343-370
Altered Mitochondrial Metabolism in Circulatory Shock....Pages 371-373
Discussion of presentation by A.G.B. Kovach....Pages 375-378
Back Matter....Pages 379-385

✦ Subjects

Pathology