Hypoxia and Exercise

✍ Scribed by James S. Milledge (auth.), Robert C. Roach Ph.D., Peter D. Wagner, Peter H. Hackett (eds.)

• Publisher: Springer US
• Year: 2007
• Tongue: English
• Leaves: 354
• Series: Advances in Experimental Medicine and Biology 588
• Edition: 1
• Category: Library

✦ Synopsis

The 14^th volume in the series will focus on cutting edge research at the interface of hypoxia and exercise. The work will cover the range from molecular mechanisms of muscle fatigue and muscle wasting to whole body exercise on the world’s highest mountains. State of the art papers on training at high altitude for low altitude athletic performance will also be featured.

✦ Table of Contents

Front Matter....Pages i-xv
A Tribute to John Burden West....Pages 1-6
Adventures in High-Altitude Physiology....Pages 7-16
Exercise Induced Arterial Hypoxemia: The role of Ventilation-Perfusion Inequality and Pulmonary Diffusion Limitation....Pages 17-30
Intrapulmonary Shunt During Normoxic and Hypoxic Exercise in Healthy Humans....Pages 31-45
Exercise-Induced Arterial Hypoxemia: Consequences For Locomotor Muscle Fatigue....Pages 47-55
Mechanisms of Sleep Apnea at Altitude....Pages 57-63
Control of Cerebral Blood Flow During Sleep and The Effects of Hypoxia....Pages 65-73
Neural Consequences of Sleep Disordered Breathing: The Role of Intermittent Hypoxia....Pages 75-88
Finding the Genes Underlying Adaptation to Hypoxia Using Genomic Scans for Genetic Adaptation and Admixture Mapping....Pages 89-100
An Evolutionary Model for Identifying Genetic Adaptation to High Altitude....Pages 101-118
Hypoxic Preconditioning and Erythropoietin Protect Retinal Neurons from Degeneration....Pages 119-131
Blocking Stress Signaling Pathways with Cell Permeable Peptides....Pages 133-143
JNK Pathway as Therapeutic Target to Prevent Degeneration in the Central Nervous System....Pages 145-155
Salvage Of Ischemic Myocardium: A Focus on JNK....Pages 157-164
Mitochondrial Reactive Oxygen Species are Required for Hypoxic HIFα Stabilization....Pages 165-170
Hypoxia-Induced Gene Activity in Disused Oxidative Muscle....Pages 171-188
Role of the Red Blood Cell in Nitric Oxide Homeostasis and Hypoxic Vasodilation....Pages 189-205
Expression of the Heterotrimeric G Protein Gi and ATP Release are Impaired in Erythrocytes of Humans with Diabetes Mellitus....Pages 207-216
Red Blood Cells and Hemoglobin in Hypoxic Pulmonary Vasoconstriction....Pages 217-231
Dose-Response of Altitude Training: How Much Altitude is Enough?....Pages 233-247
The Eye at Altitude....Pages 249-270
Lake Louise Consensus Methods for Measuring the Hypoxic Ventilatory Response....Pages 271-276
Pulmonary Hypertension in High-Altitude Dwellers: Novel Mechanisms, Unsuspected Predisposing Factors....Pages 277-291
Gene Hunting in Hypoxia and Exercise....Pages 293-309
Back Matter....Pages 311-353

✦ Subjects

Human Physiology; Neurosciences; Anesthesiology; Cardiology; Biochemistry, general