Tissue Factor Expression during Coculture of Endothelial Cells and Monocytes
✍ Scribed by Jun C. Lewis; Nancy L. Jones; M.I. Hermanns; Oliver Röhrig; Christoph L. Klein; C.James Kirkpatrick
- Book ID
- 112243876
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 912 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0014-4800
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Endothelial cells (EC) from human aortas, microvessels, and pulmonary arteries were examined for their expression and activity of monocyte chemotactic protein-1 (MCP-1), tissue factor, and thrombomodulin in response to tumor necrosis factor-␣ (TNF␣) on the hydrophilic plasma polymers ␥-butyrolactone
Tissue factor (TF) is a glycoprotein which acts as a trigger of the coagulation cascade. TF expression may be induced at the surface of monocytes and endothelial cells by several stimuli including bacterial endotoxin U S ) and cytokines (IL1 p, TNFa) and there is a large body of evidence for the inv