Hypoxia primes endotoxin-induced tissue factor expression in human monocytes and endothelial cells by a PAF-dependent mechanism
✍ Scribed by J. M. Herbert; D. Corseaux; A. Lale; A. Bernat
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 934 KB
- Volume
- 169
- Category
- Article
- ISSN
- 0021-9541
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✦ Synopsis
Tissue factor (TF) is a glycoprotein which acts as a trigger of the coagulation cascade. TF expression may be induced at the surface of monocytes and endothelial cells by several stimuli including bacterial endotoxin U S ) and cytokines (IL1 p, TNFa) and there is a large body of evidence for the involvement of hypoxia as a primaring factor in the process leading to thrombosis. To define the molecular basis underlying this phenomenon, we evaluated the relative role of platelet activating factor (PAF). PAF primed human monocytes and human umbilical vein endothelial cells (HUVEC) for TF expression following exposure to f. coli LPS but was unable to enhance the induction of TF expression by IL1 p. The priming