✦ LIBER ✦

Tissue distribution of LY231617, an antioxidant with neuroprotectant activity, in the rat

✍ Scribed by Marcus E. Brewster; Wesley R. Anderson; Emil Pop; Nicholas S. Bodor; Jill A. Panetta; Kerry S. Estes

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 341 KB
Volume: 84
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600840702

No coin nor oath required. For personal study only.

✦ Synopsis

The tissue distribution of a butylated phenol antioxidant, LY231617, which has been shown to exert potent neuroprotection action was examined. Preliminary pharmacokinetic examination suggests that LY231617 was eliminated in a biphasic fashion after iv administration to the rat with a distribution half-life of 5 min and an elimination half-life of close to 2.5 h. The volume of distribution of the compound was large (7.4 L), consistent with its lipophilic structure. Dosing paradigms that have historically resulted in pharmacologically relevant activity were examined and were found to generate brain tissue levels of LY231617 of approximately 45 micrograms/g.

📜 SIMILAR VOLUMES

Assessing the antifungal activity, pharm

Assessing the antifungal activity, pharmacokinetics, and tissue distribution of amphotericin B following the administration of Abelcet® and AmBisome® in combination with caspofungin to rats infected with Aspergillus fumigatus

✍ Kishor M. Wasan; Olena Sivak; Michael Rosland; Verica Risovic; Karen Bartlett 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 232 KB

The purpose of this study was to assess the antifungal activity, pharmacokinetics, and tissue distribution of amphotericin B (AmpB) following the administration of Abelcet and AmBisome alone and in combination with Caspofungin to rats infected with Aspergillus fumigatus. Aspergillus fumigatus inocul

Increased activity of guanosine 3′-5′-cy

Increased activity of guanosine 3′-5′-cyclic monophosphate phosphodiesterase in the renal tissue of cirrhotic rats with ascites

✍ Paolo Angeli; Wladimiro Jiménez; Rosalia Veggian; Silvano Fasolato; Roberta Volp 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB

A possible defect of guanosine 3Ј-5Ј-cyclic monophosphate (cGMP) content in the renal tissue caused by an increased activity of cGMP phosphodiesterase (PDE) has, so far, not been evaluated in the pathogenesis of renal resistance to endogenous natriuretic peptides (ENP) in cirrhosis with ascites. To

Study of quinalphos (an environmental oe

Study of quinalphos (an environmental oestrogenic insecticide) formulation (Ekalux 25 E.C.)-induced damage of the testicular tissues and antioxidant defence systems in Sprague-Dawley albino rats

✍ Dipankar Debnath; Tapas Kumar Mandal 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 110 KB 👁 2 views

The effect of quinalphos (O-O-diethyl-O-[quinoxalinyl-(2)-thionophosphate]), an environmental oestrogenic organophosphorus insecticide pollutant, was studied on Sprague-Dawley albino rats at doses of 250 and 500 microgram kg(-1) body wt. i.p. for 3, 8 and 15 days, respectively. After the treatment w

Microsurgical repair after crush-avulsio

Microsurgical repair after crush-avulsion injury of the femoral vein in rats: Prevention of microvascular thrombosis with recombinant human tissue-type plasminogen activator (rt-PA)

✍ Efstathios G. Lykoudis; George B. Contodimos; Dimosthenis A. Tsoutsos; Konstanti 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 284 KB

## Abstract Vein thrombosis is often encountered in microsurgery, especially in the case of crush‐avulsion injuries. The aim of this study was to investigate the effect of systemic administration of recombinant tissue‐type plasminogen activator (rt‐PA) on the patency of the femoral vein of the rat,

Evaluation of the Novel Potassium Channe

Evaluation of the Novel Potassium Channel Activator BRL 55834 as an Inhaled Bronchodilator in Guinea-pigs and Rats: Comparison with Levcromakalim and Salbutamol

✍ J.R.S. Arch; N.E. Bowring; D.R. Buckle 📂 Article 📅 1994 🏛 Elsevier 🌐 English ⚖ 395 KB

The novel potassium channel activator BRL 55834 and the prototype compound levcromakalim have been compared as inhaled bronchodilators in guinea-pigs and rats. Salbutamol was included in the guinea-pig studies. In anaesthetized guinea-pigs, inhaled BRL 55834 [ED50 = 0.9 (0.5-1.5) micrograms per anim