𝔖 Bobbio Scriptorium
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Tissue Activator of Plasminogen

✍ Scribed by LACK, CHARLES H.; YOUSUF ALI, S.


Book ID
109632248
Publisher
Nature Publishing Group
Year
1964
Tongue
English
Weight
266 KB
Volume
201
Category
Article
ISSN
0028-0836

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Defibrotide, a polydeoxyribonucleotide of mammalian origin, has been shown to reduce the blood level of the plasminogen activator inhibitor, and so to increase the activity of tissue plasminogen activator without any adverse effect. A randomized, double-blind, placebo-controlled study has been done

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## Abstract Tissue plasminogen activator (tPA) is the only FDA‐approved treatment of thrombotic stroke and is a major parenchymal serine protease in the brain. However, it has been implicated in a plethora of brain pathologies, raising concern about its use as a safe therapeutic. tPA is thought to