Tirucallane Triterpenoid Saponins from Munronia delavayiFranch

✍ Scribed by Xiang-Hai Cai; Zhi-Zhi Du; Xiao-Dong Luo

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: German
• Weight: 176 KB
• Volume: 90
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200790205

✦ Synopsis

Abstract

Four new tirucallane triterpenoid saponins, named munronosides I–IV (2–5), along with three known triterpenoids, sapelin B (1), melianodiol, and (3__β__)‐22,23‐epoxytirucall‐7‐ene‐3,24,25‐triol, were isolated from the EtOH extract of the whole plants of Munronia delavayi Franch by chromatographic methods. On the basis of spectroscopic evidences, the structures of 2–5 were elucidated as (20__S__,23__R__,24__S__)‐21,25‐epoxy‐29‐{{O‐β‐d‐glucopyranosyl‐(1→3)‐O‐[α‐l‐rhamnopyranosyl‐(1→6)]‐β‐d‐glucopyranosyl}oxy}‐23,24‐dihydroxytirucall‐7‐ene‐3,21‐dione (2), (3__β__,20__S__,23__R__,24__S__)‐21,25‐epoxy‐29‐{{O‐β‐d‐glucopyranosyl‐(1→3)‐O‐[α‐l‐rhamnopyranosyl‐(1→6)]‐β‐d‐glucopyranosyl}oxy}‐3,23,24‐trihydroxytirucall‐7‐en‐21‐one (3), (20__S__,23__R__,24__S__)‐24‐(acetyloxy)‐21,25‐epoxy‐29‐{{O‐β‐d‐glucopyranosyl‐(1→3)‐O‐[α‐l‐rhamnopyranosyl‐(1→6)]‐β‐d‐glucopyranosyl}oxy}‐23‐hydroxytirucall‐7‐ene‐3,21‐dione (4), and (3__β__,20__S__,23__R__,24__S__)‐24‐(acetyloxy)‐21,25‐epoxy‐29‐{{O‐β‐d‐glucopyranosyl‐(1→3)‐O‐[α‐l‐rhamnopyranosyl‐(1→6)]‐β‐d‐glucopyranosyl}oxy}‐3,23‐dihydroxytirucall‐7‐en‐21‐one (5).