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TIMP-2 promotes cell spreading and adhesion via upregulation of Rap1 signaling

✍ Scribed by Hyeujin Chang; Jungeun Lee; Haryoung Poo; Makoto Noda; Terre Diaz; Beiyang Wei; William G. Stetler-Stevenson; Junseo Oh

Book ID
116292971
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
387 KB
Volume
345
Category
Article
ISSN
0006-291X

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## Abstract Calcium‐regulated non‐receptor proline‐rich tyrosine kinase 2 (Pyk2) is a critical mediator of endothelin‐1 (ET‐1) signaling in human glomerular mesangial cells (GMC). We aimed to identify which small G‐protein is acting downstream of Pyk2. Dominant interfering Pyk2 construct, termed ca