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Timing and sequence of hyperthermia in fractionated radiotherapy of a murine fibrosarcoma

✍ Scribed by Yasumasa Nishimura; Muneyasu Urano

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
929 KB
Volume
27
Category
Article
ISSN
0360-3016

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The significance of time-dose relationships in the use of local tumor hyperthermia (LTH) when combined with radiation (RAD) was studied in a murine fibrosarcoma. RAD, either alone or combined with LTH, was delivered in four equal fractions (total doses, 1.8 to 4.2 krad) separated by 1 to 4 days. LTH

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## Abstract A transplantable methylcholanthrene‐induced fibrosarcoma of female BALB/c mice (the MC‐2 fibrosarcoma) was dissociated by combined mechanical and enzymatic means, then fractionated by isopycnic centrifugation in linear albumin gradients. In some experiments recovered cells were both cu