The significance of fractionation regimens in radiation and combined hyperthermia using a murine fibrosarcoma
✍ Scribed by Eric W. Hahn; Alan A. Alfieri; Jae Ho Kim
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 266 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
The significance of time-dose relationships in the use of local tumor hyperthermia (LTH) when combined with radiation (RAD) was studied in a murine fibrosarcoma. RAD, either alone or combined with LTH, was delivered in four equal fractions (total doses, 1.8 to 4.2 krad) separated by 1 to 4 days. LTH (43.1 C * .05 C for 15 minutes, water bath) was applied immediately after RAD. In this tumor system, RAD was most effective when delivered every 2nd or 3rd day, by a factor of 1.25 over the response achieved when the four fractions were delivered every 1 or 4 days. At all levels studied, RAD + LTH produced-a superior tumor response compared to RAD alone. The ratio of the RAD + LTH/RAD doses to achieve an isobiological response ranged from 1.7 to 2.5. Most significant was the finding that the RAD + LTH treatment response was independent of the fractionation scheme used and more dependent on the total RAD dose delivered.