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Time to reach steady state and prediction of steady-state concentrations for drugs obeying Michaelis-Menten elimination kinetics

✍ Scribed by John G. Wagner


Book ID
112514092
Publisher
Springer
Year
1978
Tongue
English
Weight
780 KB
Volume
6
Category
Article
ISSN
1573-8744

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πŸ“œ SIMILAR VOLUMES


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For single bolus administration, intermittent bolus administrations to steady-state, a single dose as a zero order input, intermittent zero order inputs to steady-state, and continuous zero order input to steady-state, and for both simple Michaelis-Menten elimination and parallel Michaelis-Menten an

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A problem of substantial delay in reaching the steady state drug concentration in particular organ (compartment) compared to the time of reaching the steady state plasma concentration is considered. It is shown that the ratio of the terminal (V(beta)) and the steady state (V(ss)) volumes of distribu