Michaelis—Menten elimination kinetics: Areas under curves, steady-state concentrations, and clearances for compartment models with different types of input
✍ Scribed by Dr. John G. Wagner; Gregory J. Szpunar; James J. Ferry
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 782 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0142-2782
No coin nor oath required. For personal study only.
✦ Synopsis
For single bolus administration, intermittent bolus administrations to steady-state, a single dose as a zero order input, intermittent zero order inputs to steady-state, and continuous zero order input to steady-state, and for both simple Michaelis-Menten elimination and parallel Michaelis-Menten and first order elimination, the appropriate equations are given for the areas, A U C 0-~a or A U C 0-t, steady-state concentrations, and clearances. Some 20 new equations have been derived. For the case of first order input and Michaelis-Menten elimination. no solution is given but the effect of input rate on systemic availability is reported following some numerical integrations.
The effect of slow input in reducing systemic bioavailability when Michaelis-Menten elimination kinetics are operative is stressed and the implications of this in the field of sustained-release medication mentioned.
KEY WORDS
Michaelis-Menten elimination Bolus. zero order and first order input Parallel Michaelis-Menten and first order elimination Areas under curves Clearances
Systemic availability as a function of input rate under concentration-time curves and clearances for linear and nonlinear compartment models. However, there has been no systematic study covering various types of input when elimination kinetics are those of Michaelis and Menten or parallel Michaelis-Menten and first order. It is the purpose of this article to give expressions for areas and clearances, if possible, for both of these types of elimination when input is a single bolus, intermittent boluses to